Treatment In Pregnancy for Hepatitis C: The TiP-HepC Registry
CGHE launched the TiP-HepC project on December 3rd at the International Viral Hepatitis Elimination Meeting (IVHEM). In the video on the right, Dr. Neil Gupta, Chief Technical Officer for the Coalition for Global Hepatitis Elimination, presents an abstract on the TiP-HepC project at IVHEM.
Contribute cases to TiP-HepC registry here
Background
Hepatitis C virus (HepC) antenatal screening is now recommended in the US and is increasingly the standard of care globally. However, there are no current interventions to reduce perinatal HepC transmission. Virologic suppression via the use of direct-acting antiviral (DAA) medications during pregnancy may reduce risk of mother-to-child HepC transmission, but there is very limited data regarding the safety and efficacy profile of DAAs for mother-infant pairs and off-label use of DAAs is determined on a case-by-case basis.
The Treatment In Pregnancy for Hepatitis C: The TiP-HepC Registry project is an initiative of the Coalition for Global Hepatitis Elimination (CGHE) at the Taskforce for Global Health and supported by the Centers for Disease Control and Prevention.
Project Goal
The goal of the TiP-HepC project is to consolidate and leverage existing data and engage a community of practice among relevant stakeholders to prospectively inform appropriate decision-making for HepC treatment in pregnancy.
Project Objectives
The objectives of the TiP-HepC project are to:
- Compile the existing knowledge, evidence, and initiatives related to HepC treatment in pregnancy. This includes sharing, aggregation, and analysis of existing data within HepC treatment programs globally demonstrating outcomes of mother-infant pairs exposed to DAA treatment during pregnancy or breastfeeding as a result of either intentional treatment or incidental exposures.
- Plan prospective data sharing through a multi-country safety and effectiveness registry for mother-infant pairs exposed to DAAs. No current standardized or unified registry exists to monitor mother-infant outcomes following exposure to DAAs.
- Build a community of practice and advocacy coalition dedicated to treatment for HepC in pregnant women. CGHE will develop an online knowledge hub and convene stakeholders using the knowledge generated through this project and profiling other efforts in the field.
Request for Collaboration
CGHE is seeking partners and collaborators for the TiP-HepC project to:
- Contribute existing data on outcomes of mothers and infants exposed to DAA medications in pregnancy
- Provide ideas, support, or case enrollment for a prospective registry to document outcomes of mothers and infants exposed to DAA medications in pregnancy
- Join a “Community of Practice” to learn about current evidence and efforts in the treatment of HepC for pregnancy women
Submit cases to the TiP-HepC registry here
Explore the TiP-Hep C Evidence Base here
Download the TiP-HepC Registry Evidence Brief here
For other questions contact:
Dr. Neil Gupta, Coalition for Global Hepatitis Elimination, ngupta-consultant [at] taskforce.org
Contribute data to TiP-HepC registry
The TiP-HepC registry is collecting retrospective data on the outcomes of mother– infant pairs exposed to DAAs during pregnancy in routine clinical practice will be solicited and collected from participating clinical providers, health-care facilities, HCV treatment programmes, and other clinical practices worldwide.