Treatment In Pregnancy for Hepatitis C: The TiP-HepC Registry
CGHE launched the TiP-HepC project on December 3rd at the International Viral Hepatitis Elimination Meeting (IVHEM). In the video on the right, Dr. Neil Gupta, Chief Technical Officer for the Coalition for Global Hepatitis Elimination, presents an abstract on the TiP-HepC project at IVHEM.
Hepatitis C virus (HepC) antenatal screening is now recommended in the US and is increasingly the standard of care globally. However, there are no current interventions to reduce perinatal HepC transmission. Virologic suppression via the use of direct-acting antiviral (DAA) medications during pregnancy may reduce risk of mother-to-child HepC transmission, but there is very limited data regarding the safety and efficacy profile of DAAs for mother-infant pairs and off-label use of DAAs is determined on a case-by-case basis.
The Treatment In Pregnancy for Hepatitis C: The TiP-HepC Registry project is an initiative of the Coalition for Global Hepatitis Elimination (CGHE) at the Taskforce for Global Health and supported by the Centers for Disease Control and Prevention.
Request for Collaboration
CGHE is seeking partners and collaborators for the TiP-HepC project to:
- Contribute existing data on outcomes of mothers and infants exposed to DAA medications in pregnancy
- Provide ideas, support, or case enrollment for a prospective registry to document outcomes of mothers and infants exposed to DAA medications in pregnancy
- Join a “Community of Practice” to learn about current evidence and efforts in the treatment of HepC for pregnancy women
For questions contact:
Dr. Neil Gupta, Coalition for Global Hepatitis Elimination, ngupta-consultant [at] taskforce.org
Project Goal and Objectives
The goal of the TiP-HepC project is to consolidate and leverage existing data and engage a community of practice among relevant stakeholders to prospectively inform appropriate decision-making for HepC treatment in pregnancy.
The objectives of the TiP-HepC project are to:
- Compile the existing knowledge, evidence, and initiatives related to HepC treatment in pregnancy. This includes sharing, aggregation, and analysis of existing data within HepC treatment programs globally demonstrating outcomes of mother-infant pairs exposed to DAA treatment during pregnancy or breastfeeding as a result of either intentional treatment or incidental exposures.
- Plan prospective data sharing through a multi-country safety and effectiveness registry for mother-infant pairs exposed to DAAs. No current standardized or unified registry exists to monitor mother-infant outcomes following exposure to DAAs.
- Build a community of practice and advocacy coalition dedicated to treatment for HepC in pregnant women. CGHE will develop an online knowledge hub and convene stakeholders using the knowledge generated through this project and profiling other efforts in the field.
Submit Cases to the TiP-HepC Registry
Contribute existing data on outcomes of mothers and infants exposed to DAA medications in pregnancy by submitting to the Treatment in Pregnancy for Hepatitis C (TiP-HepC) Clinical Case Registry by clicking here.
The purpose of these evidence briefs is to provide consolidated and updated information from the TiP-HepC registry regarding outcomes following exposure of directacting antiviral (DAA) medications in pregnant individuals with chronic hepatitis C virus (HCV) infection. They are intended to inform joint decision making by patients and providers for the optimal management of HCV infection during pregnancy.
Community of Practice
The Coalition has convened a TiP-HepC Community of Practice through a three-part webinar series focused on 1) the challenges of linkage and treatment for hepatitis C in pregnancy, 2) practical strategies and best practices to improve linkage to care and treatment, and 3) research needs to improve clinical practice and treatment coverage for pregnant persons.
This webinar series will brings together clinicians, academics, researchers, advocates, professional societies, regulatory agencies and industry representatives to align on best practices to improve treatment for HCV in pregnancy.
You can view the webinar presentations and recordings here: