Implementation of baby boomer hepatitis C screening and linking to care in gastroenterology practices: a multi-center pilot study


Implementation of baby boomer hepatitis C screening and linking to care in gastroenterology practices: a multi-center pilot study


Younossi, Z. M.,LaLuna, L. L.,Santoro, J. J.,Mendes, F.,Araya, V.,Ravendhran, N.,Pedicone, L.,Lio, I.,Nader, F.,Hunt, S.,Racila, A.,Stepanova, M.

BMC Gastroenterology


Prospective cohort
Virus targets
Hepatitis C
HCV testing and linkage to Care
Linkage to care
Screening and diagnosis
Target populations
Adults (> 19 years of age)
Birth cohorts of adults
Country of development
United States of America
Target location
United States of America
Testing strategy
Point-of-care antibody test (rapid test), Laboratory-based PCR/RNA (confirmatory) test
Point-of-care antibody test (rapid test)
Laboratory-based PCR/RNA (confirmatory) test

Health outcomes

Receipt of antibody results,Number new diagnoses,Linkage to care,Loss to follow-up cascade

Testing Strategy

Laboratory-based PCR/RNA (confirmatory) test,Point-of-care antibody test (rapid test)



BACKGROUND: Estimates suggest that only 20 % of HCV-infected patients have been identified and <10 % treated. However, baby boomers (1945-1965) are identified as having a higher prevalence of HCV which has led the Centers for Disease Control and Prevention to make screening recommendations. The aim of this study was to implement the CDC's screening recommendations in the unique setting of gastroenterology practices in patients previously unscreened for HCV.
METHODS: After obtaining patient informed consent, demographics, clinical and health-related quality of life (HRQOL) data were collected. A blood sample was screened for HCV antibody (HCV AB) using the OraQuick HCV Rapid Antibody Test. HCV AB-positive patients were tested for presence of HCV RNA and, if HCV RNA positive, patients underwent treatment discussions.
RESULTS: We screened 2,000 individuals in 5 gastroenterology centers located close to large metropolitan areas on the East Coast (3 Northeast, 1 Mid-Atlantic and 1 Southeast). Of the screened population, 10 individuals (0.5 %) were HCV AB-positive. HCV RNA testing was performed in 90 % (9/10) of HCV AB-positive individuals. Of those, 44.4 % (4/9) were HCV RNA-positive, and all 4 (100 %) were linked to caregiver. Compared to HCV AB negative subjects, HCV AB-positive individuals tended to be black (20.0 vs. 5.2 %, p = 0.09) and reported significantly higher rates of depression: 60.0 vs. 21.5 %, p = 0.009. These individuals also reported a significantly lower HRQOL citing having more fatigue, poorer concentration, and a decreased level of energy (p < 0.05).
DISCUSSION: Although the prevalence of HCV AB-positive was low in previously unscreened subjects screened in the gastroenterology centers, the linkage to care was very high. The sample of patients used in this study may be biased, so further studies are needed to assess the effectiveness of the CDC screening recommendations.
CONCLUSION: Implementation of the Baby Boomer Screening for HCV requires identifying screening environement with high prevalence of HCV+ individuals as well as an efficient process of linking them to care.

Page updated

21 Jan 2021